The DAWN Trials, among others, support positive results for stroke patients who first receive treatment up to 24 hours after symptom onset. Current guidelines that require treatment within 6 hours or less limit clinicians’ treatment options for stroke patients when initial signs may have gone unobserved, or when the patient may have been delayed in getting to the ER. Emerging guidelines are opening a much larger window of opportunity through which we can properly diagnose and treat stroke victims.